The Pharmacokinetics of Drugs Commonly Studied during Clinical Trials

The presenter will discuss a very important area in clinical trial research and translation, i.e. pharmacokinetics, which is the effect of the body on a particular drug, for drug classes commonly studied during clinical trials: diuretics, proton pump inhibitors, sulfonylureas, selective serotonin reuptake inhibitors (SSRIs) and angiotensin converting enzyme (ACE) inhibitors.

In addition, we will also learn how clinical trial researchers measure the pharmacokinetics of drugs. Essential pharmacokinetic metrics will be presented, and we will discuss what they can tell us about the effectiveness (or non-effectiveness) of a drug. These metrics include CMAX, CMIN, tMAX and AUC (area under the curve).

Finally, we will talk about the contradictions for the above drug classes based on their pharmacokinetic profile. Pharmacokinetics is not only very interesting but also essential for pharmaceutical translators or those wishing to enter this field. As translators, we must understand the concept(s) behind the words we translate to deliver the best translation possible.

This webinar will give you a solid foundation for pharmacokinetics as it relates to clinical drug trials and especially to the five drug classes that will be discussed.

Participants will receive a .pdf version of the presentation, a resource list and a list of the technical terms we cover during the session.